Eye Specialist & Ophthalmic Surgeon - Medical Retina · Uveitis · Cataract Surgery

About Dr Chang

Dr John Chang Dr John Chang is a consultant eye surgeon dedicated to providing the best possible care for his patients using the latest in medical research and technology combined with his specialist knowledge and skills.

Dr Chang graduated in medicine and surgery from the University of NSW with first class honours. After completing his specialist ophthalmology training in Australia, Dr Chang was awarded the prestigious Royal Australian & New Zealand College of Ophthalmologists (RANZCO) Eye Foundation scholarship to obtain further subspecialist fellowship training in Medical Retina & Uveitis at Moorfields Eye Hospital, London, UK. In London, Dr Chang had the privilege of working with some of the leading ophthalmologists in the world.

Dr Chang has been awarded a PhD in ocular immunology, for his innovative medical research with Prof Peter McCluskey and Prof Denis Wakefield at the University of NSW. He continues to work closely with these internationally renowned experts in inflammatory eye diseases. Dr Chang has made significant contributions to the medical literature, having extensively authored numerous peer-reviewed journal publications and book chapter. He continues to be actively involved in medical research and is a Senior Lecturer at the School of Medical Sciences, University of NSW.

Dr Chang's areas of clinical expertise include the diagnosis and treatment of age-related macular degeneration (AMD), diabetic retinopathy, retinal vascular diseases, uveitis and cataract surgery. He is experienced in performing retinal laser treatment, complex cataract surgery in the presence of retinal disease, and intraocular injection treatments for retinal diseases.

Professional memberships & affiliations

Dr John Chang
  • Fellow of the Royal Australian & New Zealand College of Ophthalmologists (FRANZCO)
  • Adjunct Senior Lecturer, University of NSW, Sydney
  • Full medical board registration, General Medical Practitioner and Specialist Registration, Medical Board of Australia & Australian Health Practitioner Regulation Agency (AHPRA)
  • Member of the Australian Medical Association (AMA)
  • Member of the American Academy of Ophthalmology (AAO)
  • Member of the Australian & New Zealand Society of Retinal Specialists (ANZSRS)
  • Member of Australian Society of Ophthalmologists (ASO)
  • Alumni member and past fellow, Moorfields Eye Hospital, London
  • Academic staff member and life-time alumni member, University of NSW, Sydney

Academic awards & achievements

  • NH&MRC Medical Postgraduate Research Scholarship (2003-2006)
  • University Award, First class honours in Medicine and Surgery (Faculty of Medicine, UNSW)
  • John Hirshman International Health Scholarship – To participate in the Fred Hollow's Foundation/Tilganga Nepal Eye Program (1999, School of Public Health, UNSW)
  • G.R. Cameron Memorial Prize – For the highest mark in Pathology (1997, Faculty of Medicine, UNSW)
  • W.E. Glover Prize for Physiology – For the best performance in Medical Physiology (1997, Faculty of Medicine, UNSW)

Research grants & interests

Dr Chang is involved in clinical research in the areas of uveitis, diabetic retinopathy and other retinal diseases. By bringing together his unique combination of expertise as both a clinician and a scientist, he hopes to discover new and better treatments for patients with sight-threatening eye conditions.

  • National Health & Medical Research Council (NH&MRC) Project Grant (2007-2009): The role of toll-like receptors in ocular inflammation.
  • Ophthalmic Research Institute of Australia (ORIA) Research Grant (2007): The role of IL-17 in the pathogenesis of uveitis.
  • NH&MRC Traveling Research Grant (2005). Clinical study of prostaglandin analogues in the treatment of ocular hypertension and glaucoma in patients with uveitis. Moorfields Eye Hospital, London.


Chang JH, Wakefield D. Uveitis - a global perspective. Ocular Immunology & Inflammation 2002; 10(4): 263-279

McCluskey P, Chang JH, Singh R, Wakefield D. Methotrexate therapy for ocular cicatricial pemphigoid. Ophthalmology 2004; 111(4): 796-801

Chang JH, McCluskey P, Wakefield D. Expression of toll-like receptor 4 and its associated lipopolysaccharide receptor complex by resident antigen presenting cells in the human uvea. Investigative Ophthalmology & Visual Science 2004; 45(6): 1871-1878

Wakefield D, Chang JH. Epidemiology of uveitis. International Ophthalmology Clinics 2005; 45(2): 1-13

Chang JH, McCluskey PJ, Wakefield D. Paediatric uveitis in Sydney. Clinical & Experimental Ophthalmology 2005; 33(3): 336

Chang JH, McCluskey PJ. Ocular cicatricial pemphigoid: manifestations and management. Current Allergy & Asthma Reports 2005; 5(4): 333-338

Chang JH, McCluskey PJ, Wakefield D. Acute Anterior Uveitis and HLA-B27 (Major Review). Survey of Ophthalmology 2005; 50(4): 364-388

Chang JH, O'Donnell BA. Medial canthal tendon release and lower eyelid retractor plication for Centurion syndrome. Clinical & Experimental Ophthalmology 2006; 34(3): 284-285

Chang JH, McCluskey PJ, Wakefield D. Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease. British Journal of Ophthalmology 2006; 90: 103-108

Chang JH, O'Donnell BA. Secondary tarsoconjunctival flap following previous lower eyelid Hughes repair. Ophthalmic Plastic and Reconstructive Surgery 2006; 22(2): 105-108

Chang JH, McCluskey PJ, Grigg JR. Recurrent hypopyon in chronic anterior uveitis of pauciarticular juvenile idiopathic arthritis. British Journal of Ophthalmology 2006; 90(10): 1327-1328

Chang JH, Hampartzoumian T, Everett E, Lloyd A, McCluskey PJ, Wakefield D. Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis. Investigative Ophthalmology & Visual Science 2007; 48(4): 1711-1717

Chang J, Girgis L. Clinical use of anti-TNFα biological agents: A guide for GPs. Australian Family Physician 2007; 36(12): 1035-1038

Sallam A, Comer RM, Chang JH, Grigg JR, Andrews R, McCluskey PJ, Lightman S. Short-term safety and efficacy of intravitreal triamcinolone acetonide for uveitic macular edema in children. Arch Ophthalmol 2008; 126 (2): 200-205

Chang JH, McCluskey PJ, Missotten T, Ferrante P, Jalaludin B, Lightman SL. Use of ocular hypotensive prostaglandin analogues in patients with uveitis: Does their use increase anterior uveitis and cystoid macular edema? Br J Ophthalmology 2008; 92 (7): 916-921

Badenoch PR, Mills RA, Chang JH, Sadlon TA, Klebe S, Coster DJ. Pythium insidiosum keratitis in an Australian child. Clinical & Experimental Ophthalmology 2009; 37(8): 806-9

Chang JH, McCluskey PJ, Wakefield D. Acute anterior uveitis and HLA-B27: What's new? In: Pleyer U, Forrester JV (eds). Uveitis and Immunological Disorders. Essentials in Ophthalmology. Heidelberg, Germany: Springer 2009; 9-18

Chui JJ, Li MW, Di Girolamo N, Chang JH, McCluskey PJ, Wakefield D. Iris pigment epithelial cells express a functional LPS receptor complex. Investigative Ophthalmology & Visual Science 2010; 51(5): 2558-67

Wakefield D, Gray P, Chang J, Di Girolamo N, McCluskey P. The role of PAMPs and DAMPs in the pathogenesis of acute and recurrent anterior uveitis. Br J Ophthalmology 2010; 94(3): 271-274

Chang JH, Raju R, Henderson TR, McCluskey PJ. Incidence and pattern of acute anterior uveitis in Central Australia. Br J Ophthalmology 2010; 94(2):154-156 Wakefield D, Chang JH, Amjadi S, Maconochie Z, Abu El-Asrar A, McCluskey P. What is new HLA-B27 acute anterior uveitis. Ocul Immunol Inflamm 2011; 19(2): 139-44

Chang JH, Landers J, Henderson TR, Craig JE. Prevalence of uveitis in indigenous populations presenting to remote clinics of Central Australia. Clinical & Experimental Ophthalmology 2011 Nov 2. Doi: 10.1111/j.1442-9071.2011.02726.x. (Epub ahead of print)

Karampelas M, Kopsachilis N, Chang JH, Pal B. [Intravitreal bevacizumab for choroidal neovascularisation in a patient with Membranoproliferative Glomerulonephritis Type II] Der Ophthalmologe [article in German] (in press)

Chang JH, Jang JD, Jamieson RV, Grigg JR. Long-term follow-up study of autosomal dominant optic atrophy in an Australian population. Asia-Pacific Journal of Ophthalmology March/April 2012; 1(2): 88-90.

Chang JH, Mills RA, Pater J, Crompton JL. Case series of cat scratch-inflicted full-thickness corneal lacerations and a review of the literature. Clinical & Experimental Ophthalmology 2012 Mar 7. doi: 10.1111/j.1442-9071.2012.02783.x. [Epub ahead of print]

Chang JH, McCluskey PJ, Wakefield D. Recent advances in toll-like receptors and acute anterior uveitis. Clinical & Experimental Ophthalmology 2012 Mar 19. doi: 10.1111/j.1442-9071.2012.02797.x. [Epub ahead of print]